In the collaborative atorvastatin diabetes study cards, treatment with atorvastatin 10 mg compared. Learn vocabulary, terms, and more with flashcards, games, and other study tools. In the collaborative atorvastatin diabetes study cards, the effect of atorvastatin calcium on cardiovascular disease cvd endpoints was assessed in 2838 subjects 94% white, 68% male, ages 40 to 75 with type 2 diabetes based on who criteria, without prior history of cardiovascular disease and with ldl. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atovastatin diabetes study cards. Random allocation to atorvastatin, 10 mgd, or placebo, with a median followup of 3. A post hoc analysis of data from the collaborative atorvastatin diabetes study cards, a randomised, placebocontrolled trial of 2,838. Atorvastatin reduced the death rate by 27% 48 to 1, p0. It lowers the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors. Effect of atorvastatin on glycaemia progression in patients. Pdf design of the collaborative atorvastatin diabetes study. The study is funded by diabetes uk, the department simvastatin there was a significant reduction of 25% in the of health and pfizer uk manufacturers of atorvastatin. The aim of this study was to evaluate the effect of atorvastatin on lipid lowering, cardiovascular cv events, and adverse events in women compared with men in 6 clinical trials. Atorvastatin reduced cv events even in low ldl dm patients.
Hitman was copi and rotating chair of the academically led cards study in type 2 diabetes 5. Based on the clinical cards data, the favourable cost effectiveness of atorvastatin 10mg in. Mar 18, 2020 the effect of atorvastatin on fatal and nonfatal cardiovascular disease was also assessed in a randomised, doubleblind, multicentre, placebocontrolled trial, the collaborative atorvastatin diabetes study cards in patients with type 2 diabetes, 4075 years of age, without prior history of cardiovascular disease, and with ldlc. A landmark lipitor study of patients with type 2 diabetes. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. A multicenter study in malaysia to determine the efficacy and safety of a generic atorvastatin n punithavathi, dch, l m ong, frcp, y l l lena, msc, s leekha, md, on behalf of the storvas clinical trial study group clinical research centre, penang hospital, residency road 10990 pulau pinang, malaysia, ranbaxy malaysia sdn bhd original. Lipitor atorvastatin calcium clinical studies pfizer medical. Atorvastatin was recently approved for the latter indication in france, based on the results of the collaborative atorvastatin diabetes study cards 2 3 4.
Colhoun hm1, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, thomason mj, mackness mi, charltonmenys v, fuller jh. Baseline characteristics in the collaborative atorvastatin. Comparison of rosuvastatin and atorvastatin for lipid. Talk with your doctor and family members or friends about deciding to join a study.
An analysis from the collaborative atorvastatin diabetes study cards helen m. Cards is designed to show if lowering cholesterol with atorvastatin in type 2 diabetics without cv disease reduces the risk of cv events cards the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The safety and tolerability of atorvastatin 10 mg in the. Collaborative atorvastatin diabetes study cards 2838 primary prevention patients no ascvd with type 2 diabetes at least 1 other cv risk factor such as smoking, hypertension, retinopathy, or microalbuminuria ldlc levels. The trial was stopped 2 years earlier than planned because of significant benefit at the second interim analysis. Objective to assess the representativeness of the heart protection study hps and the collaborative atorvastatin diabetes study cards for incident statin users. Patients with type 2 diabetes mellitus have a high risk of developing cardiovascular cv disease. Atorvastatin effectiveness and safety in cardiology patients.
Collaborative atorvastatin diabetes study listed as cards. Primary prevention of cardiovascular disease with atorvastatin in. Methods the study population comprised 2,739 people taking part in the collaborative atorvastatin diabetes study cards who were randomised to receive atorvastatin. Contribution to cards collaborative atorvastatin diabetes study. Fiftyone children with type 1 diabetes mellitus dm1 participated in a double blinded, randomized, crossover pilot study to determine whether 12 weeks of daily atorvastatin 20 mg daily would reduce arterial stiffness and improve endothelial function. The mean baseline ldlc of the study population was 3. Ironically, there is a very compelling clinical trial showing the value of one statin, lipitor atorvastatin, in type 2 diabetes the collaborative atorvastatin diabetes study known as cards. The effect of statins on risk of heart failure hf hospitalization and hf death remains uncertain. Collaborative atorvastatin diabetes study american. The aim of the collaborative atorvastatin diabetes study cards was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. Safety of atorvastatin in the collaborative atorvastatin.
May be harmful by inhalation, ingestion, or skin absorption. Ezetimibe added to statin therapy after acute coronary. An overview of cards collaborative atorvastatin diabetes. Oct 01, 2015 choosing to participate in a study is an important personal decision.
We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1,129 patients aged 6575 years. Design a populationbased analysis with linked register data. An analysis from the collaborative atorvastatin diabetes study cards. Costeffectiveness of primary prevention of cardiovascular. Lipidlowering statin therapy reduces the proportional risk as effectively in older patients as in younger individuals. An overview of cards collaborative atorvastatin diabetes study. Objective rates of cardiovascular disease are highest in the elderly. Lipid, longterm intervention with pravastatin in ischemic disease trial. Design of the collaborative atorvastatin diabetes study cards. In the collaborative atorvastatin diabetes study cards, the effect of lipitor atorvastatin calcium on cardiovascular disease cvd endpoints was assessed in 2838. The collaborative atorvastatin diabetes study cards. Atorvastatin 10 mg daily is safe and efficacious in reducing the risk of first cardiovascular disease events, including stroke, in patients with type 2 diabetes without high ldlcholesterol.
Current statin indications and atorvastatin clinical testing 1999 6 major objective of the atorvastatin clinical study program. Cards is designed to show if lowering cholesterol with. Effects of atorvastatin on kidney outcomes and cardiovascular. No excess of adverse events was noted in the atorvastatin group. In the collaborative atorvastatin diabetes study cards, the effect of lipitor atorvastatin calcium on cardiovascular disease cvd endpoints was assessed in 2838 5. Study cards was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. Population 56 963 patients with diabetes initiating statin use from 2005 to 2008. A multicenter study in malaysia to determine the efficacy and.
Mar 05, 2012 ironically, there is a very compelling clinical trial showing the value of one statin, lipitor atorvastatin, in type 2 diabetes the collaborative atorvastatin diabetes study known as cards. The collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebo. Impact of female sex on lipid lowering, clinical outcomes. The collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary. The clinical benefit of use of statins in patients with type 2 diabetes has been demonstrated in several randomized, controlled trials, including the cards clinical trial. Atorvastatin competitively inhibits hepatic hydroxymethylglutaryl coenzyme a reductase, the enzyme which catalyzes the conversion of hmgcoa to mevalonate, a key step in cholesterol synthesis. The primary endpoint, time to the first occurrence of acute coronary events, coronary revascularisation or stroke, was significantly reduced by 37% in patients treated with. In the incremental decrease in end points through aggressive lipid. Lipitor atorvastatin calcium side effects, images, uses. To provide scientific answers to many of the remaining questions in the area of lipidology and the clinical consequences of atherosclerosis. It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Atorvastatin reduced major cardiovascular disease events in. Ppt atorvastatin clinical study program powerpoint. Pdf effects of atorvastatin on kidney outcomes and. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study cards. In the collaborative atorvastatin diabetes study cards, treatment with atorvastatin 10.
May 18, 2006 cards is designed to show if lowering cholesterol with atorvastatin in type 2 diabetics without cv disease reduces the risk of cv events cards the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Aspen atorvastatin study for prevention of coronary heart disease endpoints in noninsulindependent diabetes mellitus. Secondary analysis demonstrated potential reduction of arterial stiffness following atorvastatin therapy p 0. In the collaborative atorvastatin diabetes study cards, the effect of lipitor on cardiovascular disease cvd endpoints was assessed in 2838 subjects. Apr 23, 2019 atorvastatin is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors. Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the collaborative atorvastatin diabetes study cards diabetologia, dec 2005 h. Atorvastatin is used to lower bad cholesterol and triglycerides in the blood. Collaborative atorvastatin diabetes study cards in cards see clinical studies involving 2,838 subjects age range 3977 years, 32% women. For general information, learn about clinical studies. In the collaborative atorvastatin diabetes study cards, the effect of lipitor on cardiovascular disease cvd endpoints was assessed in 2838 subjects 94% white, 68% male, ages 4075 with type 2 diabetes based on who criteria, without prior history of cardiovascular disease and with ldl. The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the collaborative atorvastatin diabetes study cards and followed for 3. Main outcome measures we determined the proportions of realworld.
Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus colhoun hm, betteridge dj, durrington pn, et al. The collaborative atorvastatin diabetes study cards recently investigated the effects of lipid lowering with statin therapy specifically in patients with type 2 diabetes. Teaching and learning taught masters after you graduate taught masters download a prospectus taught masters admissions process taught masters fees for taught masters study. The collaborative atorvastatin diabetes study cards, comparing treatment with atorvastatin lipitor, pfizer inc with placebo in 2800 patients with type 2 diabetes but without overt heart.
Collaborative atorvastatin diabetes study cards or card. Renal effects of atorvastatin and rosuvastatin in patients. Are statin trials in diabetes representative of realworld. The collaborative atorvastatin diabetes study cards randomised patients to either atorvastatin 10mg per day or to placebo. Trials like the collaborative atorvastatin diabetes study cards, proved beyond doubt that patients with type 2 diabetes and other risk factors for cvd should be treated with a statin, apparently disregarding their. Feb 11, 2011 the american diabetes association has recommended using statins a class of drug used to lower cholesterol levels for patients with type 2 diabetes. However, few reports have directly compared the renoprotective effects between potent and conventional statins. Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus. Cost effectiveness of atorvastatin in patients with type 2.
Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. Material may be irritating to the mucous membranes and upper respiratory tract. In brief, cards was a multicentre, randomised, placebocontrolled trial in 2,838 patients with type 2 diabetes aged 4075 years carried out in 2 centres in the uk and ireland. Collaborative atorvastatin diabetes study cards or card study free subscriptions for doctors and students. To estimate the costeffectiveness of atorvastatin 10 mg compared with no treatment for the primary prevention of. The study population comprised 2,739 people taking part in the collaborative atorvastatin diabetes study cards who were randomised to. Renoprotective effects of atorvastatin compared with. Several studies have shown that statins suppress the progression of diabetic nephropathy. The collaborative atorvastatin diabetes study cards randomized placebocontrolled trial. Nct00327418 has been described in detail previously.
The collaborative atorvastatin diabetes study cards was the first completed statin trial to be conducted exclusively in people with type 2 diabetes without known cvd. Ofthe collaborative atorvastatin diabetes study cards inthe belgian population marbaix s1,vandenberghe h1,van gaal l2 1p. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes cards overview 1 a multicenter randomized placebo controlled trial to determine hard outcomes of atorvastatin 10mg vs. To describe baseline characteristics of patients in the collaborative atorvastatin diabetes study cards, a randomized, placebocontrolled trial of lipid lowering with atorvastatin 10 mg daily for the primary prevention of major cardiovascular events in patients with type 2 diabetes. Abstract background there are few data on the role of lipid lowering in the primary prevention of coronary heart disease chd in diabetic. Side effects of lipitor atorvastatin calcium, warnings, uses.
The goal of the collaborative atorvastatin diabetes study cards trial was to determine the effectiveness of the lipidlowering agent atorvastatin in reducing cardiovascular events and death among diabetic patients with at least one heart disease risk factor, but without elevated cholesterol. Safety of atorvastatin in the collaborative atorvastatin diabetes study cards the safety and efficacy of sta the safety and efficacy of statins for cvd prevention is well established, yet some physicians have concerns about the longterm safety of this class. These guidelines are based on numerous trials showing a benefit for statin therapy both as primary and secondary prevention of cardiovascular disease and mortality 27. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of preexisting vascular disease and who had only average or below average cholesterol levels. Effect of atorvastatin on glycaemia progression in.
Allhatlltantihypertensive and lipidlowering treatment to prevent heart attack trial. The collaborative atorvastatin diabetes study cards is a multi centre, randomized, placebocontrolled, doubleblind clinical trial of primary prevention of cardiovascular disease in patients. Pdf primary prevention of cardiovascular disease with. Patients with type 2 diabetes and no prior cvd n 2,838. Nov 12, 2005 the aim of this study was to determine the pattern of the effect of the 3hydroxy3methylglutaryl coenzyme a reductase inhibitor atorvastatin on cardiovascular events in patients with type 2 diabetes and no prior history of cardiovascular disease cvd. Colhoun hm, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, charltonmenys v, demicco da, fuller jh. American diabetes association indications for statins in. Rapid emergence of effect of atorvastatin on cardiovascular. He helped design the study, seek funding from diabetes uk, nhs and pfizer and had close involvement in the management and success of the study. Atorvastatin is in a class of medications called hmgcoa reductase inhibitors statins. Although it is known that type 2 diabetes is associated. Atorvastatin 10mg filmcoated tablets summary of product. Pediatric atorvastatin in diabetes trial padit rti.
The effects of lowering ldl cholesterol with statin. This study aimed to estimate the cost effectiveness in the belgian setting of atorvastatin 10 mg compared with no treatment for the primary prevention of cv. Although the study was not powered for a direct comparison between the two statins, results of both planet i and ii suggest that atorvastatin and rosuvastatin have different renal profiles in patients with proteinuria, whereas the effects on lipids are similar, with a larger effect of rosuvastatin 40 mg than of atorvastatin 80 mg. Openurl1crossref2pubmed3web of science4 q in patients with type 2 diabetes mellitus, is atorvastatin better than. Based on the clinical cards data, the favourable cost effectiveness of atorvastatin 10 mg in patients with type 2 diabetes has been demonstrated in countries such as the uk and france. The collaborative atorvastatin diabetes study cards is the first randomized controlled trial that assessed the effectiveness and safety of using atorvastatin in patients with type 2 diabetes.
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